Italian striker Andrea Belotti is expected to be given the chance to lead Roma in their upcoming Europa League fixture.
As reported by La Repubblica, Roma will look to bounce back from their defeat to Slavia Praha before their international break with a heavily rotated squad.
Among the players to be rested is supposedly Romelu Lukaku. The newspaper suggests Jose Mourinho will start Belotti ahead of him.
Meanwhile, Houssem Aouar will likely start ahead of Lorenzo Pellegrini who recently made his long-awaited return from injury. The Algerian midfielder will play alongside Bryan Cristante and Leandro Paredes.
Finally, Nicola Zalewski and Zeki Celik will both have the chance to start on either wing in place of Spinazzola and Karsdorp.