Roma are looking to bounce back after their disappointing draw with Servette on Thursday night.
Mourinho and his men are set to travel to Reggio Emilia to face Sassuolo on Sunday.
Italian media reports suggest that the likes od Gianluca Mancini and Rick Karsdorp will return to Roma’s starting XI.
Rui Patricio, Spinazzola, Cristante and Pellegrini will all make appearances from the start as well.
Dybala and Lukaku will lead the attack once again, with Sardar Azmoun ready to come off the bench.