Coming off their third defeat in six games, the Giallorossi will be forced to adapt in defence after Diego Llorente was diagnosed with a hip flexor strain that will keep him out for two weeks. He’ll join fellow injured defenders Chris Smalling and Marash Kumbulla on the sidelines—forcing Jose Mourinho to utilise Bryan Cristante in their place.
Meanwhile, Frosinone have drawn their previous two matches after handling Sassuolo in mid-September. Eusebio Di Francesco will be without without injured trio Abdou Harroui, who recently underwent surgery for a broken toe, Francesco Gelli, and veteran fullback Pol Lirola.
ROMA (3-5-2): Rui Patricio; Mancini, Cristante, Ndicka; Karsdorp, Aouar, Paredes, Pellegrini, Spinazzola; Dybala, Lukaku
Unavailable: Tammy Abraham, Marash Kumbulla, Diego Llorente, Renato Sanches, Chris Smalling
FROSINONE (4-3-3): Turati; Oyono, Okoli, Romagnoli, Marchizza; Mazzitelli, Barrenechea, Brescianini; Soulé, Cheddira, Baez
Unavailable: Abdou Harroui, Pol Lirola, Francesco Gelli, Kaio Jorge