José Mourinho lost a huge contributor and leader in Henrikh Mkhitaryan as the Armenian went down with a muscle strain in the first leg of the Conference League semifinals at King Power Stadium.
The ex-Borussia Dortmund man is expected to miss at 15 days, if not more.
For the moment, the Special One will have to find alternative solutions to keep Roma’s midfield afloat.
The Portuguese technician is likely to replace Mkhitaryan with Sergio Oliveira from the start on Thursday night, reports Il Tempo.
Oliveira will partner up with Cristante in the middle of the pitch, with Zalewski and Karsdorp securing the flanks.
Chris Smalling – who was rested in the scoreless draw with Bologna – will return to starting eleven after an impressive performance in the first leg in England.